THE UNIVERSITY OF QUEENSLAND

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Lead-free perovskite materials for solar cells and beyond Category: Humanities, Arts and Social Sciences (HASS) Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Targetting Prostaglandin D2 Pathway for Enhanced Therapy in Atopic... Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

The brain-immune interface: implications for sleep and mood Category: Humanities, Arts and Social Sciences (HASS) Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Mapping the tumour microenvironment in cutaneous scc - dynamic responses... Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Denosumab vs zoledronic acid for the treatment of moderate-to-severe... Category: Medical Research

ARC National Competitive Grants · FY 2025 · 2025-01

Next Generation Newton-type Methods with Minimum Residual Solver. Optimisation methods play a crucial role in many applications. Among them, Newton-type algorithms hold a special place due to their desirable properties. However, the underlying challenge remains effective solution of their complex subproblems. Leveraging recent advances in numerical linear algebra, this project aims to address this challenge directly and revolutionise Newton-type algorithms for diverse optimisation scenarios. The project is expected to pioneer new theory and open-source implementations that hold the potential to reshape the landscape of optimisation research. Among the benefits are facilitating the development of effective optimisation algorithms for machine learning and enhancing knowledge extraction from modern datasets. Field of research: 4903 - Numerical and Computational Mathematics Optimisation methods are the central mathematical tools in training modern machine learning models, often representing a computational bottleneck and a major contributor to the costs and carbon footprints associated with large-scale training processes. In this light, optimisation methods that efficiently utilise computational resources are crucial. Newton-type optimisation methods achieve this by leveraging the problem's geometric structure. However, a critical yet often overlooked aspect in their development is efficiently solving their subproblems, which is essential for their success and adoption. This project aims to innovate mathematical methods that can revolutionise Newton-type optimisation algorithms, with a focus on subproblem solvers. The project's outcomes include methods that efficiently utilise available computational resources, offering tangible economic and environmental benefits, including reduced costs and carbon footprint in large-scale machine learning computations. These methods will be made accessible to Australian businesses and researchers relying on machine learning tools through the development of open-source software compatible with existing industrial machine learning platforms. This will be accompanied by case studies, tutorials and online courses to facilitate the translation of academic research into practical knowledge for practitioners and industry members, as well as to help with the realisation of these economic and environmental benefits.

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Mobile DNA decides neuronal fate in the normal and degenerative human... Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Understanding the hidden costs of working long hours Category: Humanities, Arts and Social Sciences (HASS) Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Melanoma detection with terahertz quantum technology: accurate early... Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

"COVID and; Beyond": Innovative rapid response nanoprobes to detect the... Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Combatting Alzheimer's disease with platelet-derived bioactive molecules Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Mobile DNA decides neuronal fate in the normal and degenerative human... Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Mechanisms and first prophylactic treatments of neurogenic heterotopic... Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Finding the genetic variants influencing antidepressant withdrawal... Category: Medical Research

ARC National Competitive Grants · FY 2025 · 2025-01

Understanding avian innate immunity to improve avian influenza surveillance. Highly pathogenic avian influenza virus (HPAIV) threatens Australian livestock and wild animal populations. Aberrant innate immune responses cause tissue damage in susceptible, but not tolerant species. This project will reveal the molecular mechanisms underpinning innate immune signalling differences between HPAIV-susceptible (chicken) and tolerant (duck) species. This project will also determine if these differences in innate immune signalling are conserved in predicted HPAIV-susceptible and tolerant wild bird species. Expected outcomes include novel insights into avian immunology and innate immune signalling and new strategies to predict species susceptibility to HPAIV for significant agricultural, conservation and biosecurity benefits. Field of research: 3204 - Immunology Emerging viruses, like highly pathogenic avian influenza (HPAIV), cause severe disease and death in domestic poultry livestock and wild birds. Some species, such as ducks, can carry HPAIV with minimal disease, meaning they can easily spread viruses. The immune response is the best protection against viral infection, yet in HPAIV-susceptible species (such as chickens), immune overactivation may cause collateral tissue damage, driving disease. We have identified an immune pathway that is overactive in chickens compared with ducks. This research project will uncover why this immune pathway is overactive in chickens but not ducks and whether this immune pathway is also overactive in native Australian birds. With this knowledge, we can better predict which native birds may act as HPAIV carriers (like ducks) and which birds are at high risk of death (like chickens). Our findings will improve HPAIV surveillance and Australian biosecurity to protect our poultry and livestock industries and our wild birds. This research proposal will also generate fundamental new knowledge about how this immune pathway functions in infection, which we anticipate may also generate new intellectual property. The project will employ and train Australian scientists in immunology and increasing their employability in academia, industry and government. Project outcomes will be published in open-access journals and will be shared with government (e.g. Biosecurity QLD), wildlife organisations and industry.

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Enabling precision medicine for oesophageal cancer patients Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Lost in translation: why flaviviruses induce cleavage of tRNAs Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

New diagnostic strategies for antibiotic-resistant infections Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Preclinical validation of anti-tubercular conjugated oligoelectrolytes Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Exploration of the skin molecular ecosystem and early melanoma... Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Immune Dashboard Chip (IDC): Single-molecule digital nanotechnology for... Category: Medical Research

ARC National Competitive Grants · FY 2025 · 2025-01

Unlocking crop epigenomics to uncover and engineer hidden diversity. Considering the immense pressure to meet global food demand, this project aims to explore new avenues to boost the production of Australia’s most important crops. We aim to utilise revolutionary new technology to understand how hidden factors beyond the sequence of genes could be harnessed for crop improvement across generations and environments. Expected outcomes of the project include world-first deep insight into the fundamental biology of epigenomics in sorghum, barley and wheat and development of novel technological approaches to high-throughput DNA methylation profiling and genome engineering. Foreseeable benefits include knowledge and technological capacity to fine-tune underexploited yield components for improved grains production. Field of research: 3108 - Plant Biology Australia’s agriculture industry generates $80B annually and has the ambitious goal of reaching $100B by 2030. Grains, including sorghum, wheat and barley, are the second most profitable component of the industry, making up approximately 28% of the gross value. Powered by genetics, producers have steadily increased the yields of grain crops over decades; however, gains are stagnating and it is clear that genetics alone cannot explain the differences in yields between our newest varieties. Enabled by a world-first Australian-innovated technology, this project will investigate if the chemical structure of DNA itself can explain yield differences. This is akin to testing if changing the grammar in a sentence can more efficiently convey its meaning. Project outcomes, including understanding the basis of improved yield, combined with our diagnostic tools, have great potential to help producers to develop higher yielding crops more rapidly, potentially increasing yield beyond current limits. Our technology is a breakthrough in cost-effective screening of plants, and through our connections with Australian crop improvement programs we will explore the potential for industry adoption. The approaches developed in this project could have broad applicability to challenges faced by Australian farmers including crop quality, nutrition, disease tolerance and climate resilience, which could increase the future profitability and sustainability of food production.

ARC National Competitive Grants · FY 2025 · 2025-01

Understanding human brain plasticity and sensory perception. This project will examine how sensory areas of the human brain alter during sensory learning and how such changes in brain structure and function lead to improvements in sensory perception performance. We use cutting-edge methods that we have developed for ultra-high resolution functional brain imaging (7 Tesla MRI) and computational modelling to study markers of brain plasticity at a level never previously possible in the living human brain. The project therefore investigates the fundamental basis of human brain plasticity for sensory learning. This will provide critical new understanding of the micro-level function in sensory areas of the human brain that underpin sensory learning and perception. Field of research: 5202 - Biological Psychology This project will answer fundamental questions about how the brain adapts and changes in response to everyday life experiences, known as brain plasticity. The brain’s ability to adapt and learn through sensory experience is essential for normal human development throughout life, for learning and acquisition of new skills, and for recovery of abilities following injury. As such, this research provides a crucial knowledge-base for applications in sensory learning and training programs, human-machine robotics developments, and interventions for rehabilitation following stroke or amputation. Our research will also develop MRI technology and computational methods that allow examination of the living human brain with unprecedented detail. We use ultra-high field MRI, using one of only two such MRI scanners in Australia (a major resource under the National Imaging Facility). Through our research program, we provide an advanced training ground for Australian scientists and MRI-technologists in human brain imaging, as well as translation into new medical imaging capabilities and clinical applications. Our research outcomes and computational tools will be promoted and shared through open-source repositories and open-access reports/publications, allowing broad and immediate translation and adoption. MRI advances will also be translated commercially through our existing MRI industry partners.

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Minimally-Invasive Electromagnetic Haemoglobin Sensing Category: Medical Research

GrantConnect (Australian Government grants) · FY 2025 · 2025-01

Assessing the mineral security dimensions of multi-dimensional poverty Category: Humanities, Arts and Social Sciences (HASS) Research