MONASH UNIVERSITY

ARC National Competitive Grants · FY 2017 · 2017-01

Informal sanctions and bad social norms. This project aims to improve the understanding of informal sanctions to enforce compliance with social norms. Unlike most behavioural economics studies, this project examines norms leading to outcomes that are inefficient, unjust or cruel, such as honour-killings or parochial violence. This project develops experimental paradigms to study "bad" norms in the laboratory. It will investigate a setting in which co-operation is inefficient; the use of sanctions to segregate groups; and the emergence of honour norms and their implications. The project aspires to build a platform that can lead to effective policies against harmful social norms. Field of research: 1402 - Applied Economics

ARC National Competitive Grants · FY 2017 · 2017-01

Quantitative structural health assessment of large membrane-like structures. This project aims to develop a new approach, based on remote sensing and computational modelling, to assess and manage the structural health of large floating covers used for odour control and biogas harvesting to prevent unexpected failures. The project has potential benefits for high-value-added manufacturing and maintenance of these floating covers by Australian industry. Field of research: 0913 - Mechanical Engineering

ARC National Competitive Grants · FY 2017 · 2017-01

Drivers of effective T cell immunity. This project aims to investigate the mechanisms underpinning an effective immune response. In doing so, the project expects to decipher the various determinants of T cell immunity and explore how these determinants are integrated to generate effective immunity. The project will use a multidisciplinary approach to investigate antigen abundance and developmental, structural, and molecular aspects of T cells, expecting to significantly enhance our fundamental understanding of mechanisms underpinning functional T cell responses, build interdisciplinary collaborations, and significantly advance the field of T cell biology. Field of research: 1107 - Immunology

ARC National Competitive Grants · FY 2017 · 2017-01

ARC Research Hub for Processing Lignocellulosics into High Value Products. The ARC Research Hub for Processing Lignocellulosics into High Value Products aims to convert renewable and readily-available biomass material and waste streams from the Australian Pulp, Paper and Forest Industry into new, high-value products that are in high demand in existing and developing markets. The Research Hub will translate leading scientific discoveries in biomass conversion into the manufacture of advanced materials that can be used in the industries of the future. Research aims to identify new applications and products. They will be derived from lignocellulose through the advent of new smart paper packaging, green chemical and materials with unique properties. Benefits will flow to the pharmaceutical, chemicals, plastics and food packaging industries. Field of research: 0912 - Materials Engineering

ARC National Competitive Grants · FY 2017 · 2017-01

Understanding planetary-scale reorganisations in plate tectonics. This project aims to investigate the dynamics of Earth’s tectonics and its plate motions, with the aim of understanding the mechanisms that force single plates or whole-Earth motions’ changes. The Earth’s tectonics follow regular cycles, in every ~500 million years, of continental aggregation and dispersal, which are intervened by periodic destabilisation and rapid reorganisations. What causes the reorganisations and reversal of the tectonics remain standing questions in planetary dynamics. The expected outcomes of the project will provide an understanding of the recent supercontinent formation and its fragmentation into the present-day continents. Field of research: 0404 - Geophysics

ARC National Competitive Grants · FY 2017 · 2017-01

How does developmental plasticity shape adaptation to environmental change? This project aims to address how animals adapt to environmental change by examining a process largely ignored in current studies: how the environment alters animal development. This project expects to generate new knowledge in the area of the genetics of adaptation using an innovative approach to determine how genetic variation, environmental conditions, and development interact to shape adaptation to changing environments. Expected outcomes of this project include enhancing predictions of how species respond to climate change and building capacity for international collaborations. The intended impact of this project is to increase our understanding of how animals respond to environmental change by determining how multiple environmental cues act together to alter development, and how the genetic makeup of the individual affects these responses. Field of research: 0603 - Evolutionary Biology

ARC National Competitive Grants · FY 2017 · 2017-01

Programmed cell death in host-microbe interactions. This project aims to address how host cell death, as part of the immune defence system, controls invading microbes. By following host-microbe interactions at high resolution, the project will generate new knowledge in the area of infection and immunity based on an interdisciplinary approach to discover new cell death factors. The expected outcome of this project will enhance the imaging capacity and develop new technologies in Australia by building on international collaborations, providing significant benefits to the health of the community and potential to develop innovative applications in biomedical industries. Field of research: 0601 - Biochemistry and Cell Biology

ARC National Competitive Grants · FY 2017 · 2017-01

The evolutionary genetics of adaptation in species with separate sexes. This project aims to provide new theory and analysis methods for studying the genetic basis of female and male fitness. The project expects to provide new insights into the evolutionary, genetic and demographic mechanisms that influence evolutionary genetic diversity within populations. The project will reveal how sex differences in selection affect adaptation, and provide a framework for predicting whether populations with separate sexes are able to persist under changing environmental conditions. By developing a rigorous theoretical foundation for sex-specific adaptation – including genome inference methods that follow logically from the theory – the proposal will define new approaches for studying evolutionary processes in natural populations. Field of research: 0603 - Evolutionary Biology

ARC National Competitive Grants · FY 2017 · 2017-01

Exploring metabotropic glutamate receptor 5 bias, allostery and heteromers. This project aims to provide novel mechanistic and structural insights into metabotropic glutamate receptor 5 (mGlu5) function. The mGlu5 is an essential regulator of neurotransmission and higher order brain functions including learning and memory. This project expects to expand knowledge of the fundamental biological processes engaged by mGlu5 through exploration of three novel paradigms of receptor activity: allostery, bias and heteromerisation. Expected outcomes also include generation of new pharmacological tools through interdisciplinary collaborative research between multiple institutions. There is significant expected economic benefit through commercialisation of new tools and facilitation of novel drug discovery. Field of research: 1115 - Pharmacology and Pharmaceutical Sciences

ARC National Competitive Grants · FY 2017 · 2017-01

Tracking the molecular dynamics of adaptation with horizontal gene transfer. This project aims to track the dynamics of adaptation with gene exchange by building the first experimental evolution model that can directly observe this process. The acquisition of genes from other strains and species (horizontal gene transfer) frequently underlies bacterial adaptation, but it is unknown how this occurs. This project aims to shift understanding of how microbial populations respond to environmental challenges. There are significant benefits to be gained from understanding how microbes adapt in response to climate change and the widespread application of antibiotics, given that microbial populations form intimate associations with humans and sustain all of the world’s ecosystems. Field of research: 0603 - Evolutionary Biology

ARC National Competitive Grants · FY 2017 · 2017-01

Intruder alert! detecting and classifying events in noisy time series. This project aims to address the mathematical challenges in automated early detection and classification of intrusion events in noisy time series generated from perimeter security systems. The project expects to develop robust methods to detect intrusion events under different operating environments while ignoring nuisance events. The project will boost the global competitiveness of the Australian security industry, and enable improved event detection and classification in noisy time series to the benefit of many critical application areas beyond national security. Field of research: 0104 - Statistics

ARC National Competitive Grants · FY 2017 · 2017-01

Evolution of the alternation of generations in the land plant life cycle. This project aims to investigate the genetic and evolutionary basis of land plants’ dimorphic life cycle where a single genome can generate two body plans. Like animals, land plants spend part of their life as a diploid, where meiosis generates haploid spores. Unlike animals, these spores grow into multicellular organisms before generating gametes. The project will study a homeodomain protein encoding a gene family that controls the haploid to diploid transition in unicellular algae and fungi. It will investigate land plant genes in a flowering plant and a liverwort. These findings could help scientists understand and manipulate important processes such as pollen and seed production. Field of research: 0603 - Evolutionary Biology

ARC National Competitive Grants · FY 2017 · 2017-01

Mitochondria, maternal inheritance and the evolution of male life-histories. This project aims to unravel the extent to which maternal inheritance of the mitochondrial DNA renders it susceptible to accumulating mutations that are harmful only to males; an evolutionary theory called ‘Mother’s Curse’. Left unchecked, Mother’s Curse could threaten the long-term viability of populations. This project will combine experimental techniques in ecology, fruit fly genetics and a platform for measuring physiological phenotypes to test three hypotheses central to the theory. By testing these hypotheses, the project intends to understand the causes of sex differences in physiology, longevity and reproductive health, and improve awareness of evolutionary concepts that may ultimately affect human health. Field of research: 0603 - Evolutionary Biology

ARC National Competitive Grants · FY 2017 · 2017-01

Microeconomic effects of Australian natural disasters. This project aims to describe and identify the effects of Australian natural disasters – such as the Black Saturday bushfires and the Brisbane floods – on important microeconomic outcomes, including health, education and employment. Natural disasters have profound economic and social effects on individuals and communities. This project intends to bring evidence on how disasters affect individuals and how the effects can be lessened. The project expects to inform policy-makers on these critical issues by analysing field, survey and administrative data on individuals before and after past disasters. Field of research: 1402 - Applied Economics

ARC National Competitive Grants · FY 2017 · 2017-01

Dynamics and control of fluid-structure-free surface interactions. This project aims to research the apparently opposing effects of vortex shedding and free surface damping, individually and jointly, and the control or excitation of the vibrations for two generic bluff bodies: the cylinder and the sphere. Flow-induced vibrations of bluff bodies under or piercing water surfaces can damage floating off-shore marine structures and tethered bodies. On the other hand, harvesting energy from ocean currents needs large flow-induced vibrations. The intended outcomes are new modes of body vibration, wake transitions and means to control fluid-structure interactions. This research could benefit many processes in offshore marine engineering, submarine bodies and mixing vessels, where understanding and controlling fluid-structure interactions of bluff bodies can mitigate costly and dangerous induced vibrations. Field of research: 0915 - Interdisciplinary Engineering

ARC National Competitive Grants · FY 2017 · 2017-01

Patients’ use of digital media. This project aims to determine how Australians use digital media and how this influences the development and availability of treatments and the sociocultural factors underlying this digital media use. Patients can use digital media to manage their own health, but this may result in patient harm and a loss of public confidence in the underlying science. The intended outcome is to gain insights into this recent and fast-growing sociological phenomenon, and provide a scientific basis for formulating public policy strategies to ensure that healthcare resources are used efficiently and cost-effectively. Field of research: 1608 - Sociology

ARC National Competitive Grants · FY 2017 · 2017-01

How expectations shape testing in healthcare. This project aims to understand the sociocultural processes underpinning optimism for the use of testing technologies in healthcare. Australians are using more tests, which increases healthcare costs. This project will use the Australian national cancer screening programmes and routine clinical practice as case studies to determine human decision-making traits in sociological terms. The project expects to increase understanding of the sociocultural factors that influence decision-making and behaviour in healthcare settings, and help formulate effective social and economic policies. Field of research: 1608 - Sociology

ARC National Competitive Grants · FY 2017 · 2017-01

Modelling the chemical enrichment of the Milky Way. This project aims to understand the chemical and dynamical evolution of the Milky Way Galaxy from its birth to the present. Astrophysicists try to understand the production of the elements over cosmic time, using telescopes and satellites costing billions of dollars. This project will calculate the evolutionary history and detailed nuclear processes in stars of all masses and compositions. When coupled with dynamical models for stars in the Milky Way, this project will categorise how the composition changes with time, thus extracting the maximum understanding from the wealth of data to be delivered in the next few years. Field of research: 0201 - Astronomical and Space Sciences

ARC National Competitive Grants · FY 2017 · 2017-01

Spectroscopy and imaging platform for photoactive materials. This project aims to establish a comprehensive analytic tool-box to characterise solution-processable materials for thin-film solar cells based on materials such as perovskites. These materials have light harvesting properties with absorption edges beyond 800 nm. This project will focus on time-resolved transient absorption and microwave conductivity phenomena and on lock-in thermographic imaging capabilities. This will accelerate materials and technological development in this research field. This project is expected to help the local and global energy sector transition to sustainable energy, provide a competitive edge for commercialisations of solar technologies in Australia, and benefit the economy, environment and national security. Field of research: 0912 - Materials Engineering

ARC National Competitive Grants · FY 2017 · 2017-01

Gravitating relativistic material bodies: A mathematical analysis. This project aims to establish the local-in-time existence and geometric uniqueness of solutions to the Einstein-Elastic equations representing systems of gravitating relativistic material bodies, and to understand the long-time behaviour of these solutions. In spite of their importance to astrophysics, almost nothing is known about the mathematical properties of solutions to the equations of motion governing gravitating systems of relativistic material bodies. This project would provide mathematical tools for the study of gravitating relativistic material bodies and provide guidance on developing stable numerical schemes for simulations that are essential for comparing theory with experiment. This would significantly improve current understanding of the behaviour of matter and gravitational fields near the matter-vacuum boundary of bodies and help understanding of the physics of these boundaries. Field of research: 0101 - Pure Mathematics

ARC National Competitive Grants · FY 2017 · 2017-01

The validation of approximate Bayesian computation. This project aims to establish the theoretical validity of approximate Bayesian computation (ABC) and to develop diagnostic methods for assessing its reliability in empirical applications. Given the increased complexity of modern statistical models, new ways of conducting statistical inference are needed. Approximate Bayesian computation is a new statistical tool. This project expects its findings will be useful in all fields where complex phenomena feature and approximate methods are the only feasible way of understanding those phenomena. Field of research: 1403 - Econometrics

ARC National Competitive Grants · FY 2017 · 2017-01

Evolutionary limits. This project aims to understand the processes that limit adaptation to rapid environmental change. Adaption to rapid environmental change determines population persistence. Species with restricted distributions may lack the genetic variation necessary to adapt to changing environments, although they represent the vast majority of biodiversity. Understanding why they lack the necessary genetic variation for adaptation is important for identifying and managing vulnerable biological systems. This project will empirically determine the contribution of mutations to key traits to better understand what limits evolutionary adaptation. Better prediction of extinction risk should inform conservation and biodiversity management. Field of research: 0603 - Evolutionary Biology

ARC National Competitive Grants · FY 2017 · 2017-01

Legal and ethical issues in the inheritable genetic modification of humans. This project aims to investigate the legal and ethical implications of technologies that allow inheritable modifications of the human genome. The use of these technologies in human embryos is fast becoming an international reality, and this project aims to examine the implications for Australia. The project will clarify the legal status of inheritable genetic modification technologies in Australia, analyse the ethics of these new technologies, and, building on this, recommend regulatory reforms to guide Australia’s response to international scientific and legal developments. These reforms could improve the governance of these new technologies and guide their clinical adoption. Field of research: 1801 - Law

ARC National Competitive Grants · FY 2017 · 2017-01

Building the Australian response to the ‘superbugs’ crisis. This project aims to investigate the Australian public’s engagement with communications and media on antimicrobial resistance, examine the public’s trust in expert knowledge and study how the public enacts expert advice about antimicrobial drugs in everyday life. The resistance of common infections to antibiotics and other drugs (the ‘superbugs’ crisis) jeopardises health worldwide. The ‘superbugs’ crisis means that individuals and care givers need to use drugs as prescribed and reduce their expectations for drug treatments. Research findings are expected to underpin Australia’s public health policy and communications response to ‘superbugs’, improving national and international health outcomes. Field of research: 1608 - Sociology

ARC National Competitive Grants · FY 2017 · 2017-01

Consequences of temporal community turnover. This project aims to understand how environmental change affects compensatory dynamics of species. Species numbers do not change over time in local ecological communities, but species composition is changing at an unprecedented level across the globe. The implications of these compensatory dynamics for the resilience of ecological communities and how they affect ecosystems are important for community ecology and conservation. This project could reveal the functional consequences of temporal community change, contributing new insights into the effects of environmental change especially on soil ecosystems. Field of research: 0602 - Ecology