MONASH UNIVERSITY

ARC National Competitive Grants · FY 2019 · 2019-01

How limbs evolved from fins: the role of somite cells. This project aims to investigate the developmental basis of vertebrate appendage diversity and how during evolution limbs became fins. The project expects to determine how specific populations of cells that regulate fin formation arise during development, the genetic basis of their function, and how their role in development has evolved in lineages with divergent appendage anatomy. Expected outcomes include understanding the molecular basis of the fin-limb transition and the origin of divergent appendage patterning systems. This should provide significant benefits by advancing our knowledge of the relationship between evolution and development, and understanding limb defects, which are amongst the most common of human congenital malformations. Field of research: 0603 - Evolutionary Biology

ARC National Competitive Grants · FY 2019 · 2019-01

Efficient and fair context-aware resource allocation in networks. This project aims to develop a flexible mathematical framework for internet resource allocation among competing demands by exploiting application context to allocate resources more efficiently. The project will extend an existing framework which allocates resources independently at each time period, by considering benefits over periods of time relevant to users. The expected outcome of this project is a systematic method for designing next-generation congestion-avoidance protocols that anticipate and accommodate different types of demand. This project will provide significant benefits including better provision of internet services and new ways to help combat traffic congestion, bringing benefits to both the environment and society. Field of research: 0805 - Distributed Computing

ARC National Competitive Grants · FY 2019 · 2019-01

Aggregation control for high-performance polymer electronics. This project aims to exploit the behaviour of semiconducting polymer chains in solution to realise high-performance polymer electronics. This project will be achieved through a combination of simulation, theory, and X-ray measurements of solution-phase chain conformation and device studies. The project expects to create new predictive understanding of how the self organisation of semiconducting polymer chains determines thin-film microstructure and thus charge transport in thin-film devices. Expected outcomes include new materials and processes for high-performance polymer transistors and enhanced interdisciplinary research partnerships. This approach should hasten the development of new technologies based on lightweight flexible electronic devices. Field of research: 0303 - Macromolecular and Materials Chemistry

ARC National Competitive Grants · FY 2019 · 2019-01

Muscle memory: The key to novel interactive memory support systems. This project aims to investigate how the use of muscle memory as a deliberate interaction design resource can effectively support declarative memory. The project brings together memory interaction design and bodily activity design to address increasing concerns surrounding Australians’ memory. By investigating muscle memory in interaction design, the project is expected to advance international understanding of scholarly and practical processes that complement design for declarative memory. The project will lay the foundation for extending research which will assist movement, rehabilitation, health and educational sports practitioners that can create engaging experiences that use muscle memory for the benefit of all Australians. Field of research: 1203 - Design Practice and Management

ARC National Competitive Grants · FY 2019 · 2019-01

Nuclear transport in stress. This project aims to provide key new insights into cell resistance to stress centred on subcellular transport in stress. Environmental stress in its various forms results in the breakdown of cellular functions such as conventional transport into and out of the host cell nucleus. This project will examine a nuclear transporter that has the ability to remain active in stress. Results will establish a platform for stress biology research by the evaluation of nuclear transport in stress in cellular and in-vivo models, and its impact on cell fate. These outcomes will have broad-reaching benefits for enacting climate change responses as well as enhancing Australia’s international collaborative network and providing research training opportunities. Field of research: 0601 - Biochemistry and Cell Biology

ARC National Competitive Grants · FY 2019 · 2019-01

From gene to duty: the emergence of the complex brain. This project aims to determine the molecular code (genes and their products) responsible for the expansion of the nonhuman primate visual cortex, which underpins the formation of discrete functional and anatomical areas. The project will detail all the genes expressed at key stages of brain development and how interfering with their expression inhibits the normal formation of areas. The expected outcomes are a chronological and functional map of the molecular code that underpins the formation of the complex primate visual cortex. This will contribute to defining the mechanisms leading to the evolution of the complex primate visual brain and complement the numerous brain connectome studies being undertaken globally. Field of research: 1109 - Neurosciences

ARC National Competitive Grants · FY 2019 · 2019-01

New directions in extremal and structural graph theory. This project aims to attack unsolved problems at the intersection of extremal and structural graph theory, two of the most significant branches of graph theory. Graph theory, which is the mathematics of networks, models many real-world problems and is a key component of modern mathematics. This project expects to develop a theory that synthesises the latest developments in the two fields. It is expected that the tools developed will be widely applicable, for example, in algorithms for network optimisation. The project will build collaborations between Australian researchers and world-leading international mathematicians, and will provide advanced training for talented young researchers. Field of research: 0101 - Pure Mathematics

ARC National Competitive Grants · FY 2019 · 2019-01

The integration of perception and thought. This project aims to use a new neural marker to discover and conceptualise how the brain integrates perception with thought. Combining approaches from cognitive neuroscience and the philosophy of cognitive science, the project intends to show how cognitive performance in healthy individuals depends on the degree of integration of top-down and bottom-up signals in the brain. The expected outcome is new empirical and philosophical understanding of the conditions for optimal integration of perception and thought, as well as enhanced interdisciplinary capacity and cross-institutional collaboration. The anticipated benefit is an accessible neuroimaging tool for cognitive assessment. Field of research: 2203 - Philosophy

ARC National Competitive Grants · FY 2019 · 2019-01

How neurons maintain their fate. This project aims to investigate how neurons maintain their identity, without reverting back to less specialised cells. Stable fate maintenance is essential because when it fails, cells lose their ability to perform their ascribed function, which impedes organism fitness. This project aims to define how two proteins work in partnership to maintain the identity of brain neurons. We intend our discoveries to stimulate new research, for example to test whether the human counterparts of the Drosophila proteins studied here, function similarly. Benefits will be provided in the form of job creation, and new knowledge in fundamental aspects of life, including brain development and cell fate maintenance. Field of research: 0601 - Biochemistry and Cell Biology

ARC National Competitive Grants · FY 2019 · 2019-01

Low-energy electro-photonics: novel materials, devices and systems. This project aims to develop low-power technologies for programming and tuning photonic integrated circuits (PICs). By replacing thermal tuning, the project will reduce power consumption from watts to milliwatts, which also eliminates the thermal crosstalk that limits the complexity of today's PICs. The expected outcome will be the basis for a generic field-programmable photonic chip, which can be used to rapidly prototype designs for production as full custom chips as part of a new Australian industry capability. The expected benefits will be a faster innovation cycle, greater adoption of photonic technologies, and support of research into, for example, neuromorphic optical processing, and advanced communications and sensing systems. Field of research: 1005 - Communications Technologies

ARC National Competitive Grants · FY 2019 · 2019-01

Bacterial communities in metropolitan, rural and indigenous Australians. This project aims to apply recently developed culturing methods to archive and phenotype bacterial species found in the human gut in a representative sample from metropolitan, rural and indigenous Australians. This project expects to isolate, genome sequence, classify, characterize and permanently archive 1500 bacterial species. Expected outcomes of this project include detailed knowledge of previously undiscovered bacterial species, improved methods to measure the bacterial species that inhabit the human gut and a detailed understanding of the gut microbiota of Australians. This project should significantly enhance our knowledge of bacterial diversity and evolution and provide detailed insights into bacterial transmission. Field of research: 0605 - Microbiology

ARC National Competitive Grants · FY 2019 · 2019-01

Econometric methods for distributional policy effects. This project aims to develop new econometric methods that can measure distributional policy effects by accounting for heterogeneous policy impacts among observationally equivalent individuals. The project expects to develop quantile regression methods under a difference-in-differences framework that accommodates issues of censoring and sample selection. The outcomes of this project are expected to substantially broaden the scope of the standard mean difference-in-differences approach and have significant contributions to empirical studies in the future. The project intends to provide statistically valid inferential procedures and conduct simulation exercise and empirical studies relevant to policy evaluation for the benefit of Australia and other jurisdictions. Field of research: 1403 - Econometrics

ARC National Competitive Grants · FY 2019 · 2019-01

The visual politics of populism. This project aims to investigate the visual politics of populism across the globe. Against a backdrop of unprecedented success of populists worldwide, the project will use six international case studies to comparatively examine how populists use visual media, how visual media covers populists, and the audience effects of these practices. Expected outcomes include enhanced insight into the linkages between populism, visual legitimacy and democracy, and a deeper understanding of contemporary populism’s appeal. This project expects to inform how mainstream parties and civil society groups can better deal with populists, as well as informing best practice on how media can cover populists. Field of research: 1606 - Political Science

ARC National Competitive Grants · FY 2019 · 2019-01

Conferring dignity in law and health care. This project aims to develop a new and more inclusive philosophical conception of dignity. It expects to generate an alternative to the exclusionary view that dignity is inherent since not all human beings possess the relevant inherent traits. The project will develop a conception of dignity as something conferred, and expects to show that such dignity can and should be conferred on all human beings. The expected outcome is a new understanding of the importance of dignity in human rights law and in health care services. The intended benefits are better appreciation of the role of dignity in human rights, and guidance for health and aged care services on how they can promote the dignity of all of their clients. Field of research: 2203 - Philosophy

ARC National Competitive Grants · FY 2019 · 2019-01

Wildlife responses to endocrine disruptors. This project aims to uncover how a ubiquitous agricultural endocrine disruptor affects development, survival and reproduction in frogs. Widespread pollution by endocrine disrupting chemicals poses a serious threat to wildlife, human health, and the environment. This project will integrate laboratory- and field-based experiments to provide insights into how aquatic contamination by endocrine disruptors can affect vulnerable early life stages and, in turn, adult performance and reproduction. The findings will add significantly to understanding the impact of chemical pollution on wildlife responses to human altered environments. Field of research: 0602 - Ecology

ARC National Competitive Grants · FY 2019 · 2019-01

Gross credit flows, credit reallocation, and the macroeconomy. This project aims to construct measures of credit reallocation from regulatory bank-level data for Australia and other countries. The project intends to develop empirical models able to evaluate the role of credit reallocation on aggregate output and a theoretical model with search and match frictions to evaluate quantitatively the role of bank credit in explaining macroeconomic outcomes. The project expects to provide significant benefits for policymakers for assessing the interplay between monetary and credit policy, formulating macroeconomic and macro prudential policies, and shedding light on the causes of productivity dynamics in Australia, boosting its comparative advantage. Field of research: 1402 - Applied Economics

ARC National Competitive Grants · FY 2019 · 2019-01

Understanding sperm motion at surfaces. This project aims to reveal the biophysics of sperm motion at surfaces, using 3D imaging, advanced mathematical modelling, and microfluidics. This interdisciplinary project expects to generate new knowledge of sperm flagellar activity, using an innovative microfluidic approach to measure full dynamics of sperm motion in 3D and compare experimental observations with computational results. The project is expected to reveal the intraflagellar mechanisms that trigger the switch between 3D and 2D flagellar waveforms near surfaces. This should provide significant benefits, such as important insights into the biophysics of mammalian reproduction and the origin of flagellar motility in eukaryotes. Field of research: 0915 - Interdisciplinary Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

Skin in the game: biomimetics, fitness and the springtail cuticle. This project aims to examine the relationship between cuticle (skin) properties, water balance, and fitness in springtails, key players in soil systems. Springtail cuticles are diverse, responsive, and extremely resistant to wetting by water, alcohol and other substances. Their Australian diversity has not been well explored for biomimetic new materials. This project expects to explore options for new applications in materials science and engineering by generalising the cuticle structure-function relationship. Expected outcomes are new information to harness for industry the diversity of nature’s self-cleaning, water repellent surfaces. Significant benefits lie in potential new biomimetic manufacturing options. Field of research: 0608 - Zoology

ARC National Competitive Grants · FY 2019 · 2019-01

Sustainable surfactants from Australian oilseeds. This project aims to develop a new generation of sustainable surfactants utilising Australian-grown oilseed feedstocks. These molecules are designed to replace current materials made from petroleum and palm oil, to fulfil a key role as the next generation of bio-resourced detergents and emulsifiers. The work seek to develop a library of new molecules to better understand the relationship between molecular structure and performance, through cutting edge lab testing and utilising national infrastructure, guiding the use of new components in formulating new products. It is anticipated that the surfactants generated will find uses in household cleaning and personal care products, providing high value chemicals from key Australian crops. Field of research: 0306 - Physical Chemistry (Incl. Structural)

ARC National Competitive Grants · FY 2019 · 2019-01

ARC Training Centre for Cell and Tissue Engineering Technologies. The ARC Training Centre for Cell and Tissue Engineering Technologies aims to provide training to create a highly skilled workforce for the tissue engineering and regenerative medicine sector and to enhance research performance and innovation in Australia through fundamental and applied research carried out in industry-led PhD projects. The research aims to address major aspects of the manufacturing and commercialisation pathway and barriers faced by the sector, namely improving process efficiencies, enabling early-stage scale-up (cell/tissue) and development of the sector's supply chain. The knowledge created and research undertaken would help to accelerate commercialisation in regenerative medicine, tissue engineering and cell therapies. Field of research: 1004 - Medical Biotechnology

ARC National Competitive Grants · FY 2019 · 2019-01

DNA repair: a critical quality control mechanism in the female germ line. This project aims to investigate the fundamental biological mechanisms required for the production of high quality gametes, which underpin female fertility and the propagation of all sexually reproducing species. By taking advantage of unique mouse and avian models, this project expects to define the role of the DNA repair protein TOP3A in the successful completion of meiosis and it's requirement for the survival and genetic integrity of gametes throughout their lifespan. In doing so, the intended outcome of this project is to dramatically improve our understanding of quality control in the female germ line. This should provide significant benefits to Australia by positioning it as a world leader in the field of Reproductive Science. Field of research: 0608 - Zoology

ARC National Competitive Grants · FY 2019 · 2019-01

Popular Petitioning and Mass Democracy in the United States: a History. This project aims to investigate the neglected history of popular petitioning in the United States. Across the long nineteenth century, activists organised mass petition campaigns in support of causes as diverse as antislavery, suffrage and immigration restriction. In the twentieth century, however, petitioning dwindled. The project draws on this rich archive of activism to assess the role, impact and evolution of petitioning as a democratic tool. The expected outcome is a new perspective on a vital development: the emergence of mass democracy. Furthermore, the project should provide a critical historical framework for assessing modern-day claims about the digital petition and its power to bridge the gulf between citizens and government. Field of research: 2103 - Historical Studies

ARC National Competitive Grants · FY 2019 · 2019-01

Determining the Impact of Social Protection Policy on Work Disability. . This project will develop new knowledge on the impact of social protection policy and process on work disability. The mixed methods project uses data linkage, epidemiological and qualitative methods to study the impact of policy change on access to the Disability Support Pension (DSP), the experiences of DSP applicants and recipients, and to examine the transition of people with long-term work disability between workers’ compensation and social security systems. Through multi-disciplinary and cross-sector collaborations established, it is anticipated that the Fellowship will inform future social policy development and service delivery, and develop capacity to evaluate social protection programs and policy shifts as they occur. Field of research: 1605 - Policy and Administration

ARC National Competitive Grants · FY 2019 · 2019-01

How drugs in the wild affect animal behaviour, ecosystems, and evolution. This Project aims to track – with fish species and across different modes, scales, and levels of complexity from controlled laboratory experimentation to studies in the wild – how drugs in the environment affect wildlife behaviour and survival, and therefore also the ecological communities they inhabit. Contamination of aquatic habitats by pharmaceuticals poses a serious threat to wildlife and to human health. Expected outcomes include new mechanistic understandings and predictive capability for real world application. Findings should add significantly to our knowledge of how wildlife respond to environmental change, and enhance the evidence base for management and security of Australia’s biodiversity and freshwater resources. Field of research: 0602 - Ecology

ARC National Competitive Grants · FY 2019 · 2019-01

A Reception History of Early Modern Landscape Design. This project aims to address the problem of how to develop a reception history of designed landscapes. It expects to generate new knowledge in the area of landscape history through an innovative history of early modern gardens focused on reception rather than design, a detailed case study of the experiential dimensions of the Sacred Wood in Bomarzo (Italy), and the initiation of a global reception history of gardens. Expected outcomes of this project include new methods and techniques for the analysis of landscape and enhanced capacity to build international collaborations. This should provide significant benefits for the understanding of the socio-cultural uses and preservation of heritage landscapes by both scholars and the public. Field of research: 1201 - Architecture