UNIVERSITY OF MELBOURNE

ARC National Competitive Grants · FY 2019 · 2019-01

New entropy measures of short term signals for smart wearable devices. This project aims to improve reliability and accuracy of wearable devices by developing a new set of computationally efficient algorithms. Wearable devices can be very effective in remote and continuous monitoring to detect short or bursty anomalous events. Present devices are unable to detect such events effectively due to limited capability in processing short length signal. This project will provide computationally efficient algorithms for signal quality analysis and enhanced feature extraction methods in resource constrained wearable devices. This will improve the reliability and performance of wearable devices for adoption in intelligent decision-making systems. Field of research: 0903 - Biomedical Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

Unravelling the enigma of turbulence by integrating simulation & modelling. This project will transform how turbulence and flow-induced noise is understood and predicted to help meet the challenge of ever-growing transport and energy demands in an affordable and sustainable way. This will be achieved by integrating the latest simulation advances with unique machine-learning approaches. The expected outcome will be a paradigm shift in how turbulence and noise models are created and used, informed by new scientific knowledge and data. The proliferation of these new models will allow the design and operation of more efficient, reliable and quieter technologies in the aerospace, naval and energy industries, benefitting the Australian economy and environment, and raise the international profile of our scientists. Field of research: 0915 - Interdisciplinary Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

Categorisation, communication and the local environment. Languages around the world incorporate different systems of categories, and understanding this variation can contribute to a better understanding of similarities and differences between cultures. This project examines how linguistic variation is shaped in part by variation in the local physical and social environment. The methods include computational analyses of large electronic data sets including dictionaries and linguistic corpora that have become available only recently, and psychological experiments that probe the causal mechanisms that lead to variation across languages. The outcomes include computational tools that pick out key differences between languages and therefore support cross-cultural communication. Field of research: 1702 - Cognitive Sciences

ARC National Competitive Grants · FY 2019 · 2019-01

Understanding rough-wall flows and turbulent mixing for improved models. In the absence of a reliable predictive capability for turbulent heat transfer, design engineers are currently forced to incorporate safety margins into their calculations to compensate for aero-thermal loading uncertainty, which ultimately limits the opportunities for high-efficiency designs. This project employs high-fidelity simulations and experiments of real-world heat transfer problems, as identified by our partner organisation, MHI, an industry leader, combined with a novel data-driven model development framework. Outcomes will be a fundamental advance in our predictive capability and understanding of turbulent heat transfer, which in turn will permit more reliable, efficient and durable designs for energy generation. Field of research: 0915 - Interdisciplinary Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

The Future Cemetery. This project aims to identify and critically assess the potential of innovative technologies to enhance the experience of the cemetery for an increasingly diverse, secular, and well-informed public, and to strengthen cemeteries’ community connections. It will generate knowledge about the industry’s and the public’s future-oriented desires through an interdisciplinary, collaborative, and evidence-based assessment of emerging cemetery-based technologies including mobile apps, GPS systems, drones, holography, virtual reality, green burials, and resomation. A key expected outcome is a future cemetery that makes sensitive use of technology to enhance its services to public and community, underpinned by scholarly research. Field of research: 1608 - Sociology

ARC National Competitive Grants · FY 2019 · 2019-01

DNA printing on a synthetic polymer template. This project aims to design and study DNA printing to manufacture long strands of DNA using simple but elegant fundamental non-enzymatic chemical reactions. Gene therapy is one of the most rapidly growing therapies in modern medicine but it is prohibitively expensive for the average person. Current methods of artificial gene synthesis are complicated with commercial DNA synthesis only supplying short DNA strands. The project outcomes will lead to a stable template directing the chemical reactions for DNA printing. This new approach will make life-saving gene therapy cheaper and more widely available for future generations and provide economic, and social benefits to all Australians. Field of research: 0303 - Macromolecular and Materials Chemistry

ARC National Competitive Grants · FY 2019 · 2019-01

Young people bereaved by domestic homicide. Far-reaching decisions are made about the future of a child bereaved by domestic homicide, including where they should live and whether they should have contact with the perpetrator. Practitioners and policymakers lack empirical and theoretical input to guide these decisions. This fellowship draws upon young people's, caregivers' and professionals' perspectives on children's living arrangements, relationships and identity development post-homicide. It expects to generate a theoretical model of children's outcomes as well as actionable advice for policymakers and practitioners. The main benefit will be enhanced capacity to support children, families and professionals in the context of domestic homicide in Australia and abroad. Field of research: 1607 - Social Work

ARC National Competitive Grants · FY 2019 · 2019-01

Metabolic control of organ growth and regeneration. One of the fundamental questions in biology is to understand how organ size is regulated at the cellular and organismal level. The Hippo/Yap pathway plays a central role in the regulation of organ size and it is impacted by environmental cues including nutrient status. This research proposal aims to use zebrafish to elucidate the role that the Hippo/Yap pathway plays in reprogramming lipid metabolism to fuel tissue growth in development and regeneration. Ultimately, this work aims to identify metabolic dependencies required for organ growth and regeneration. Expected outcomes include scholarly publications revealing fundamental principles underlying tissue growth, new resources for the research community and training for research students. Field of research: 0601 - Biochemistry and Cell Biology

ARC National Competitive Grants · FY 2019 · 2019-01

The rediscovery of Senecan tragedy in 14th century Europe. This project aims to provide a new understanding of the emergence of classical tragedy by reassessing how classical Latin drama was revived in 14th century Europe after a long period of neglect. Classical tragedy, which incorporates the myths of the Graeco-Roman world in its fabric, was virtually unknown from late antiquity until the high middle ages when the tragedies of Seneca became popular. In the early 14th century, commentaries by Albertino Mussato and Nicholas Trevet allowed a new readership access to these complex ancient works; this analysis also provides new insights into trends of popularity across the ages. Using recent advances in digitisation technology and scholarship, the project will establish a model for research into the history of the book, the image, and text. Field of research: 2005 - Literary Studies

ARC National Competitive Grants · FY 2019 · 2019-01

Understanding and Recognising Indigenous Law and Legal Systems. This project aims to analyse the written constitutions and laws of Indigenous nations in Canada, Australia, New Zealand and the United States. The Project expects to generate the first comparative study of written Indigenous law. It will generate new knowledge of Indigenous legal concepts that will enable settler and Indigenous officials, scholars and members of the public to better understand and recognise Indigenous law. Expected outcomes of this project include new knowledge that will improve the effectiveness of settler law by ensuring it responds to Indigenous values and aspirations; facilitate the design of Indigenous representative institutions; and assist the negotiation of treaties and other agreements. Field of research: 1801 - Law

ARC National Competitive Grants · FY 2019 · 2019-01

Statistical methods for modelling the pathways between cause and effect. This project aims to develop new biostatistical methods for addressing complex analytic questions that arise in studies of the causes of health, social, educational and other outcomes in the course of human life. These questions concern the pathways that explain how intermediate factors contribute to a statistical relationship between a probable cause of a later outcome. Mathematical and statistical innovation is needed to address them. The expected outcomes include a suite of novel methods designed to evaluate the impact of intervening to modify causal pathways, while also accommodating common complexities of data such as incompleteness. This project should provide major benefits to studies in public health, social sciences and economics. Field of research: 0104 - Statistics

ARC National Competitive Grants · FY 2019 · 2019-01

Regulating guest transport in microporous materials by electric field. This project aims to address the fundamentals and applications of regulating micropore accessibility. It has long been known that some highly adsorbing molecular sieves suddenly become inaccessible to gases below certain temperatures. Following a recent breakthrough in elucidating the mechanism of such temperature-regulated guest admission, this project will explore electrical regulation of micropore accessibility in conjunction with developing new mechanisms, materials, and control tools for applications, including tunable molecular sieves, valves and gas encapsulation devices. The outcomes of this project will generate new knowledge in the active manipulation of the admission and release of guest molecules in/out of microporous materials, and establish new expertise and capabilities that can advance gas separation, storage and sensing technologies. It is expected that this project will contribute to the long term benefit in low emission energy supplies and Australia's natural gas industry, improve the separation efficiency of our chemical industry, and boost the development of the hydrogen economy. Field of research: 0904 - Chemical Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

Molecular basis of attenuation in live Mycoplasma vaccines. This proposal aims to use an innovative approach to address an urgent issue raised by the end users of an Australian-owned poultry vaccine with an extensive global market. Recently multiple mutations have been detected in the vaccine re-isolated from vaccinated birds in the field around the world. We will apply a combination of a novel technique for targeted mutagenesis, genome sequencing, and animal experimentations, to address the significance of these mutations. Results will improve our understanding of the basis of attenuation of the vaccine, its mechanism of action, and provide commercial confidence in the safety of the vaccine, which is needed to support Australian Universities and Businesses, and the global poultry industry. Field of research: 0707 - Veterinary Sciences

ARC National Competitive Grants · FY 2019 · 2019-01

Automated assessment of data quality in biological knowledge resources. This project aims to develop methods for identifying poor quality data in biological databases. Research in biomedicine is underpinned by massive databases of biological data. Data quality is largely managed through manual curation, but automated methods to assess quality are critically needed. This project expects to develop a suite of computational tools for assessing biological data quality, utilising an innovative approach based on network analysis of database record connectivity. These tools will enable quantifying data quality at scale. Researchers, evidence-based decision-makers in biomedicine, and the analytical or predictive tools that use this data will make more reliable inferences and decisions. Field of research: 0801 - Artificial Intelligence and Image Processing

ARC National Competitive Grants · FY 2019 · 2019-01

Observed streamflow generation changes: better understanding and modelling. This Project aims to investigate drivers and triggers of variable streamflow response during and after drought and develop modelling strategies and model structures more robust to changing streamflow response. In many catchments during the Millennium Drought, streamflow generation was less than expected and hydrologic models performed poorly. After the drought, streamflow generation is yet to recover in some catchments. This Project expects to generate new knowledge about variable streamflow response to drought and develop strategies and models to robustly simulate runoff during and after changed conditions, which should provide significant benefit via better understanding and modelling of streamflow response under changing conditions. Field of research: 0406 - Physical Geography and Environmental Geoscience

ARC National Competitive Grants · FY 2019 · 2019-01

Does a teacher-led mindfulness intervention improve student outcomes? This project aims to determine if improving teacher knowledge and practice of mindfulness in the classroom, can lead to better child attention and school functioning outcomes during the early primary school years. Mindfulness is an approach that aims to improve attention, self-regulation, mental health, and cognitive functioning. Expected outcomes include new knowledge as to whether mindfulness can be integrated into classroom practice, how to best implement it, student benefits and cost-effectiveness. Findings will inform schools as to whether this approach can support students in making a positive transition to primary school that can place them on positive academic and well-being pathways and lead to benefits in their adulthood. Field of research: 1303 - Specialist Studies In Education

ARC National Competitive Grants · FY 2019 · 2019-01

Integrating quantum hyperpolarisation in nuclear magnetic resonance systems. This project aims to integrate quantum hyperpolarisation technology into state-of-the-art nuclear magnetic resonance (NMR) systems, potentially boosting the signal by several orders of magnitude. Understanding the structure and function of membrane bound peptides and proteins in cells in their native environments is critical in drug development. However, studying these biomolecules by conventional NMR under ambient conditions is challenging due to sensitivity limitations. The technology developed by this project will be a significant step forward in NMR and the new science enabled may have far reaching consequences for the study of peptides and proteins of live cells for the development of new drugs and anti-biotics, with direct societal benefits and flow-on economic benefits. Field of research: 0206 - Quantum Physics

ARC National Competitive Grants · FY 2019 · 2019-01

Architecture and industry: the migrant contribution to nation-building. This project aims to explore the post-war architectural, rural and industrial landscapes of Australia as shaped by the labour of displaced persons. Migrants after the Second World War were critical to the spatial making of modern Australia. Major federally-funded industries driving post-war nation-building programs depended on the employment of large numbers of war-displaced persons. While the immigrant contribution to nation-building in cultural terms is well-known, its everyday spatial, architectural and landscape transformations remain unexamined. This project aims to bring to the foreground post-war industry and immigration to comprehensively document a how Australia has uniquely shaped its built environment. Field of research: 1201 - Architecture

ARC National Competitive Grants · FY 2019 · 2019-01

Studying early human kidney development using stem cells. This project aims to improve our understanding of cell types, lineage relationships, cell-cell interactions and morphogenetic processes in human kidney development. Investigators have developed a method to produce multicellular kidney organoids from human pluripotent stem cells (hPSC). This project will use gene-edited reporter hPSC lines and high-res imaging to study the lineage relationships and morphogenetic mechanisms of these human kidney organoids. This project aims to validate the origin of nephrons in kidney organoids, study the origin of the renal stroma versus the nephron progenitor, and monitor nephron patterning and segmentation at a clonal level. This will improve our knowledge of human kidney development in a human model. Field of research: 0604 - Genetics

ARC National Competitive Grants · FY 2019 · 2019-01

Australian welfare policy, 1950 to 2007: continuity and disruption. This project aims to analyse Australian welfare policy from the end of the Chifley government in 1949 to the end of the Howard government in 2007. The project intends to generate new understandings about the challenges facing the income support system, the key dynamics of policy reforms such as Medicare and Superannuation, and the “exceptionalism” of the Australian model. Expected outcomes include a new database based on time-series data concerning the core income support systems from 1950 to 2020. Intended benefits include a better understanding of the sort of welfare reform needed to pay for major social risks of unemployment, poverty, aged care, disability and the needs of children. Field of research: 1606 - Political Science

ARC National Competitive Grants · FY 2019 · 2019-01

Designing offices well. This project aims to describe, quantify and analyse the impact of workspace design on workers’ satisfaction, productivity and health. The Australian market is the fastest adopter of Activity-Based Working (ABW) in the world and impacts arising from this workspace typology on workers will be significant now and in the next decade. This project will develop benchmarking for ABW offices, techniques for monitoring cognitive performance in situ, and design guidelines for health promotion. By shifting attention to design features that actually perform well, this project will provide the empirical basis needed to transform the way workspaces are designed now and in the future. It will therefore lead to greater productivity in and among workplaces. Field of research: 1201 - Architecture

ARC National Competitive Grants · FY 2019 · 2019-01

Social implications of market-based policy instruments for carbon and water. This project aims to analyse socio-cultural benefits and risks in the two significant environmental markets of carbon and water across three sites in Australia and Timor-Leste. Research into market-based policies to manage significant environmental issues is yet to fully consider socio-cultural dimensions. This project intends to document local community producers, distant investor and consumer perspectives, and incorporate these perspectives into methods for improving the operation and impact of these expanding markets. By undertaking the first systematic comparison across resources and sites, the project expects to fill a key gap in environmental scholarship and contribute to international strategies to improve social and environmental outcomes in market-based environmental policy. Field of research: 1604 - Human Geography

ARC National Competitive Grants · FY 2019 · 2019-01

Improving disease resilience in ecosystems using synthetic biology. This project aims to use the latest methods in synthetic biology to conserve species threatened by disease, through characterising and enhancing immunity. Emerging infectious diseases are a major threat to ecosystems and new methodologies are needed to fight them. Chytridiomycosis is the most devastating disease of vertebrates, causing population declines in over 200 amphibian species worldwide. The expected outcomes of the project are improved understanding and increased immunity of frogs to chytridiomycosis and restoration of frogs into the environment. The project will demonstrate the usefulness of synthetic biology to tackle disease and preserve biodiversity in the landscape for similarly threatened wildlife in Australia and overseas. Field of research: 0707 - Veterinary Sciences

ARC National Competitive Grants · FY 2019 · 2019-01

Solutions for rapid penetration into sand for offshore energy installations. This project aims to develop a fundamental understanding of the response of saturated sand in seabeds during rapid penetration by offshore site investigation tools and foundation construction. The research is using innovative physical and advanced numerical modelling techniques to quantify the significant increase in sand resistance caused by rapid penetration, enabling reliable design and reducing risk of material failure associated with the high impact forces. Expected outcomes of the project include a conceptual framework and scientific-based design tool to predict the geotechnical performance of offshore installations. The research will provide the necessary scientific advances to install, moor and service offshore wind and wave energy devices more economically and efficiently. Field of research: 0905 - Civil Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

Sea-level rise and everyday lives in small island states. This project aims to advance understanding of the impacts of sea-level rise and associated policy responses on the everyday lives of island communities. Focusing on village relocation in Fiji and fortification and land reclamation in the Maldives, the project will analyse people's changing everyday experiences and practices. The project seeks to enable international and interdisciplinary collaborations, and to produce new knowledge on the opportunities and challenges of diverse policy responses to sea-level rise. The project’s findings will be beneficial for countries facing the threat of sea-level rise, as well as national governments and international agencies that support and fund climate adaptation. Field of research: 1604 - Human Geography