THE UNIVERSITY OF ADELAIDE

ARC National Competitive Grants · FY 2019 · 2019-01

ARC Training Centre for Integrated Operations for Complex Resources. This Training Centre aims to increase value in mining through clever applications of ‘lean processing’ and train the next generation of scientists and engineers in advanced sensors and data analytics in complex resources; knowledge priorities for the mining industry. Sensor information will be linked to the resource’s in-place knowledge to enable data analytics of all embedded knowledge. Processing can then be tuned to resource attributes, maximising value ‘on the fly’. Benefits will include increasing certainty on product quality and maximising throughput and recovery. Outcomes will include new tools to rapidly model geological and geometallurgical uncertainty with sensor inputs, to track the resource to product and enhance interpretation. Field of research: 0906 - Electrical and Electronic Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

Development of genetic technology for rodent population suppression. Vertebrate pests cost Australia over $1 billion each year in agricultural losses and environmental damage and novel strategies are urgently required to tackle this massive challenge. Newly proposed “gene drives”, which might rapidly spread through populations, have enormous potential for the sustained management and even eradication of pests. Through innovative application of cutting-edge genome editing approaches, this proposal aims to develop gene drive technology in mice as a prototypical vertebrate pest species. We will also develop cutting-edge mathematical models of rodent gene drives to identify crucial parameters for efficacious employment and investigate potential for impact on non-target populations. Field of research: 0604 - Genetics

ARC National Competitive Grants · FY 2019 · 2019-01

An Australian rental housing conditions data infrastructure. This project aims to provide researchers and policy stakeholders with essential data infrastructure on Australia’s rental housing conditions. The rental sector is home to almost one third of all Australians, however we have no large-scale data infrastructure to monitor and understand it. This project will provide essential data infrastructure and make it publicly available. The project will support Australian research and policy to be underpinned by robust data and evidence in the future, enabling policy to better address the nation’s economic, social, and urban goals. Field of research: 1604 - Human Geography

ARC National Competitive Grants · FY 2019 · 2019-01

Improved seismic resilience against life-safety hazard of masonry buildings. This project aims to develop a cost-effective technique to mitigate the safety risk posed by the many unreinforced brick masonry parapets and walls which are vulnerable to seismic shock. Every Australian city has many streets lined with older unreinforced brick masonry buildings (now cafes, pubs, boutique shops) which feature parapets. The project will provide benefits to society by reducing the potential for parapet collapse and therefore reduce the total number of fatalities in an earthquake. Building owners and engineers will be benefit from the design guidance provided by this project, which will lead to a suite of fully-tested and low-cost retrofit techniques. Field of research: 0905 - Civil Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

Elucidating the mechanics of facet dislocation and fracture in the neck. This project aims to address shortcomings in understanding the mechanics of neck trauma. Understanding the mechanical factors leading to cervical facet dislocation and fracture is necessary to improve injury prevention strategies and their assessment. This project expects to generate new knowledge in the area of spinal injury biomechanics, developing and using new experimental techniques. The project expects to provide knowledge necessary to improve crash test dummy design, associated injury criteria, and computational models, which provide the potential for improved injury prevention measures and methods for assessing existing and new technologies. The anticipated benefits of this project will be significant in reducing the personal and economic burden of spinal injuries. Field of research: 0903 - Biomedical Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

Philosophical perspectives on psychedelic psychiatry. This project aims to develop a multi-level integrated theory of self-representation and self-awareness that explains the effects of psychedelic therapy in particular, and transformative experience in general. Psychedelic drugs can produce lasting psychotherapeutic benefits. The mechanism is a dramatic but temporary alteration to the ordinary sense of self, known as “ego dissolution”. However, fundamental questions about self-representation and its neural and cognitive implementation remain unresolved. In order to explain ego dissolution and its therapeutic effects, this project aims to integrate two theoretical approaches to self-representation situated at the intersection of philosophy and cognitive neuroscience, the predictive coding theory of brain function and the self-binding theory of self-representation. Such a framework has potential to anchor further interdisciplinary research and practical intervention in disorders of the self. Field of research: 2203 - Philosophy

ARC National Competitive Grants · FY 2019 · 2019-01

Adaptation of carbon free fuels to high temperature industrial processes. This project aims to deepen our understanding of the underpinning scientific and engineering solutions required to adapt carbon free renewable fuels to high temperature industrial processes. The project will advance the knowledge base of innovative strategies, such as fuel blending and oxidant stream vitiation needed to replace fossil based fuels with alternatives such as hydrogen, or ammonia. Advance experimental and computational tools will be used to investigate the controlling parameters to facilitate adaptation including burning characteristics, modes of heat transfer and pollutant emissions. The project will generate deeper understanding of the proposed approaches, detailed and unique high fidelity data, and suitable predictive models. Field of research: 0913 - Mechanical Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

Fundamental roles of aquaporin-1 channels in cell migration and morphology. This project aims to investigate cell migration mechanisms and the roles of aquaporin channels in controlling cell motility and morphology. The ability of cells to move and maintain proper shape is important for development, repair and survival in multicellular organisms. This project will test the role of mammalian aquaporin-1 channels in enabling rapid migration in normal and cancer cells, in repairing barrier layers in kidney and brain, and in allowing red blood cells to maintain the classic disk-shape needed for optimal transport. Outcomes will define features of aquaporin-1 that provide these functions, using molecular, optical and pharmacological tools. Results will define aquaporin channel properties that enable optimal cellular function. Field of research: 0606 - Physiology

ARC National Competitive Grants · FY 2019 · 2019-01

Delivering robust hydrological predictions for Australia’s water challenges. This project aims to build a virtual hydrological laboratory to identify the best hydrological models that maximise predictive performance in a range of catchments, accounting for their dominant hydrological processes and data availability. New process-informed hydrological model structures will be developed using this virtual laboratory to embody our best understanding of hydrological processes and data from real catchments. The expected outcomes include major improvements in hydrological predictions for Australian catchments. This project will provide major benefits to irrigators, water authorities and engineers, who rely on hydrological predictions for sustainable water management in the highly-variable, semi-arid Australian climate. Field of research: 0406 - Physical Geography and Environmental Geoscience

ARC National Competitive Grants · FY 2019 · 2019-01

Development of efficient CRISPR gene drives in mice. This project aims to generate new tools for vertebrate pest management through development of cutting-edge gene drive technology in mice. Vertebrate pests cost Australia over $1 billion each year in agricultural losses and environmental damage and novel strategies are required to tackle this challenge. Newly developed “gene drives”, which can rapidly spread through populations, have enormous potential for the sustained management and even eradication of pests. This project aims to develop gene drive technology in mice as a prototypical vertebrate pest species. The project will potentially deliver valuable tools that directly impact Australia’s Science and Research Priority on Food. Field of research: 0604 - Genetics

ARC National Competitive Grants · FY 2019 · 2019-01

Symmetry and geometric partial differential equations. This project aims to develop tools to assist the study of partial differential equations, which are fundamental to our understanding of the physical world. Symmetries of the Laplace equation are fundamental in both finding and interpreting its solutions and can be traced to the conformal symmetries of the underlying space. Only for the most symmetric of spaces, Euclidean space and the sphere, is this correspondence well understood. Using powerful geometric tools from conformal geometry, the project will extend this to less symmetric spaces. The knowledge generated from this project will extend to more general geometric contexts providing a concrete setting for the study of the associated natural equations in curved spaces. Field of research: 0101 - Pure Mathematics

ARC National Competitive Grants · FY 2019 · 2019-01

Towards sustainable language revival: a Kaurna case study. This project aims to increase understanding of how a language can be successfully reclaimed through a longitudinal study on the reclamation of the Kaurna language of the Adelaide Plains. Reviving Indigenous languages is a key factor in helping restore Indigenous health and well-being, and Kaurna has been a model of language revival initiatives in Australia and internationally. But despite many impressive gains, its story is still one of vulnerability. The current Kaurna movement, with its extensive records, offers a window of opportunity to examine the successes and problems since its last critical appraisal. By examining the means of success and ways of overcoming obstacles and challenges for Kaurna, this project will propose recommendations for Indigenous languages as living, viable languages into the future. Field of research: 2003 - Language Studies

ARC National Competitive Grants · FY 2019 · 2019-01

Next-generation smart water network for performance-driven asset management. This project aims to develop smart water network systems and techniques for continuous monitoring and early detection of structural failure in water distribution systems. Water assets are critical infrastructure, and they consist of a network of buried pipes that are old and deteriorating, with an annual maintenance overhead exceeding $1billion per year in Australia. This project is expected to deliver next-generation smart water technology that enables continuous assessment of the actual performance of water pipe networks, guide “just in time” pipe replacement and optimise operations. This technology will assist asset managers to make informed decisions, strategically prioritise investment and extend asset life. Field of research: 0905 - Civil Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

Next generation transport infrastructure using high performance materials. This project aims to provide structural engineers with the tools required to develop ultra-high performance fibre reinforced concrete materials and to utilise their unique material properties in design. Recent feasibility studies have shown that the replacement of conventional concrete and steel transport infrastructure with ultra-high performance fibre reinforced concrete has the potential to revolutionise the sector. For these cost savings benefits to be realised, guidelines for the low cost development and testing of new materials, and for the application in structural design are required. This project is expected to deliver these guidelines and potentially maximise the impact of government spending on road and rail infrastructure. Field of research: 0905 - Civil Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

Channels for improved crop salt and water stress tolerance. Water and salt are critical factors for the Australian agricultural industry. Crops use proteins called aquaporins to move water across cell membranes, and a newly discovered subset of these proteins can also transport salts. This project aims to reveal the molecular pathways that regulate water and salt transport via aquaporins using multidisciplinary techniques in genetics, molecular biology and electrophysiology. These results will provide novel insights into how plants coordinate and adapt to changing water and salt conditions, answering key questions in plant physiology. Benefits include an expanded, innovative range of targets for plant breeding programs to improve plant productivity in our changing climate. Field of research: 0607 - Plant Biology

ARC National Competitive Grants · FY 2019 · 2019-01

East Australian climate extremes through the Holocene. The project aims to document climate variability in eastern Australia over the Holocene, the last 11,500 years. It seeks to develop Australia’s two highest-resolution Holocene climate records using novel techniques to infer past rainfall, temperature and evaporation. The project will combine the expertise of international drought and climate specialists with novel techniques developed by the Australian investigators to derive an unparalleled record of drought duration, frequency and intensity. In particular, the project aims to determine the frequency, duration and causes of mega-droughts in eastern Australia, of which little is known. Expected project outcomes include improved decision making capacity for natural resource management, and planning. Field of research: 0406 - Physical Geography and Environmental Geoscience

ARC National Competitive Grants · FY 2019 · 2019-01

Transnational selves: French narratives of migration to Australia. This project aims to examine texts authored by French-speaking migrants to Australia in order to explore how migrating subjects write their identity, how migrants represent the self between nations and between languages, and how Australia is viewed through the prism of another language. Expected outcomes to this project include enhanced knowledge of Australian literature, of practices of migrant writing, and of the construction of Australian identity. This will provide significant benefits, such as a wider understanding of the diversity of Australian literature, an increased awareness of literature in Languages Other Than English in Australia, and a more nuanced appreciation of Australian identity. Field of research: 2005 - Literary Studies

ARC National Competitive Grants · FY 2019 · 2019-01

Heat stress in the workplace: health burden and labour productivity loss. This project aims to estimate the economic loss of workplace heat exposure in Australia. The project will investigate the health services costs of occupational heat-related illnesses/injuries, explore the labour productivity loss and its costs resulting from heat stress at work, and estimate the benefits from a generic heat warning intervention for workplace heat prevention. Outcomes are expected to provide an overview of national economic implications at present and in the future from effective heat stress control, assist the development of work place heat policies, and inform resource allocation to make Australian workplaces well prepared for likely increasing extremely hot weather. Field of research: 1117 - Public Health and Health Services

ARC National Competitive Grants · FY 2019 · 2019-01

Trade and investment in the face of declining international cooperation. This project aims to investigate the impact and policy implications of trade and investment policies in a world trade system facing increasing uncertainty. The project intends to gain an improved understanding of investment regulations like Investor State Dispute Settlement (ISDS) agreements and their impact on trade and foreign direct investment. Expected outcomes include new theories for the breakdown of international agreements and their effects on third world countries as well as empirical methods that allow for a quantification of the welfare and employment effects of investment policies like ISDS. This project should provide benefits by informing government policy makers to improve Australia’s trade and investment policies. Field of research: 1402 - Applied Economics

ARC National Competitive Grants · FY 2019 · 2019-01

Smart self-propelled nanoreactors for catalytic environmental remediation. This project aims to develop nanomaterial design and technology to enable the applications of nanotechnology for environmental remediation. Various nanomotors with different asymmetric structures will be fabricated and tested for catalytic and photocatalytic degradation of aqueous pollutants. The physicochemical properties, motion behaviour and catalytic performance will be comprehensively investigated. The outcomes of the project will underpin the development of green technologies for sustainable energy conversion and water treatment. This will provide significant benefits, putting Australia in a leading position in the sustainable development of nanotechnology for sustainable energy supply and transformation as well as environmental and biomedical applications. Field of research: 0904 - Chemical Engineering

ARC National Competitive Grants · FY 2019 · 2019-01

Investigating differences in decision-making ability in older adults. This project aims to investigate how healthy ageing impacts decision making and its associated neural circuits using computation modelling and neurogenetic methods. Decision-making is a fundamental cognitive ability, allowing us to choose the best course of action. This project will investigate the relationship between genes and decision-making performance across the adult lifespan. Expected outcomes include a deeper understanding of how decision-making evolves in healthy ageing, and a tool based on genetic scores and computational modelling to predict an individual's trajectory of cognitive function. This could help identify individuals who are at risk for cognitive decline, which could then inform better interventions. Field of research: 0604 - Genetics

ARC National Competitive Grants · FY 2019 · 2019-01

The genomic landscape of speciation in hominins and other taxa. This project will develop a new analytical framework to build detailed genomic maps of speciation genes across different taxa, to determine whether observed speciation is the result of background selection and demography alone, or whether there are actual barriers to gene flow and introgressed DNA. The model will provide novel insights into the mechanistic basis of speciation, specifically whether a common set of genes or pathways are central to the speciation process. The framework will be developed using the large genomic datasets available across a range of plant and animal species. Applying the model to a modern human population dataset will elucidate the role introgressed DNA from Denisovan and Neanderthals has played in shaping human evolutionary history and may provide novel insights into the genetic basis of disease. Field of research: 0604 - Genetics

ARC National Competitive Grants · FY 2019 · 2019-01

Evolutionary diversity optimisation. This project aims to build up and establish the area of evolutionary diversity optimisation. The project will cover the design and application of evolutionary diversity optimisation methods to complex problems of significance and high national economic benefit and build up the theoretical foundations of these methods. The project is expected benefit decision makers by providing them a diverse set of high quality alternatives to choose from. This project will allow them to make highly informed decisions and lead to more reliable solutions for optimisation problems, in areas of high economic impact such as manufacturing and supply chain management. Field of research: 0801 - Artificial Intelligence and Image Processing

ARC National Competitive Grants · FY 2019 · 2019-01

Linking supramolecular nanocages into multi-functional materials. This project aims to advance the complexity of metal-organic materials by ordering discrete nano-cage structures called "metal-organic polyhedra" in a multi-functional porous solid. The project expects to generate critical knowledge in the synthesis of high-performance materials by combining the advantages of metal-organic and dynamic covalent chemistry. The expected outcomes of the project include the development of materials that are able to sequentially catalyse chemical reactions in a single-batch process. This project should deliver benefits for Australia’s emerging chemical manufacturing industry, such as a reduction in the cost, wastage and environmental impact of the chemical manufacturing industry. Field of research: 0303 - Macromolecular and Materials Chemistry

ARC National Competitive Grants · FY 2019 · 2019-01

Towards herbicide cocktails with a new mode of action to avert resistance. This project aims to target herbicide resistant weeds which represent one of the largest threats to Australian and global food security. Targeting of unexplored pathways in plants to develop a novel herbicide strategy is expected to be achieved, and will include the structural and functional characterisation of key enzymes in these pathways. This project is expected to provide significant benefits for effective weed management to sustain Australia’s agricultural industry through enhanced food production from increased crop yields, whilst ensuring food security. These outcomes, coupled with decades of over-reliance on current herbicides, means there has never been a greater need for new and effective herbicides. Field of research: 0607 - Plant Biology